These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). wAd**CgI%"nn{Oa[q{r5 To help make sure that you dont miss an appointment for your Injectafer dose, try setting an appointment reminder on your phone. Possibleside effectsareweight gainand suicidal thoughts. Brandon ColbyMD, a medical expert specializing in preventive medicine and clinicalgenomics. IQVIA [NSP Audit from MAT November 2013 to November 2018]. This is only a brief summary of general information about this medicine. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. A boxed warning is the most serious warning the Food and Drug Administration (FDA) can issue about a drug. 2. Iron sucrose can also be mixed in a. And this would give you a total cumulative Injectafer dose of 1,440 mg. Injectafer should be given in two doses. Cardiovascular health: Insomnia linked to greater risk of heart attack. How long does iron infusion stay in your system? People with IDA have low blood levels of hemoglobin. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. This medication is given by injection into a vein as directed by your doctor. Joint pain. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. The recommended dosing guidelines of Injectafer for treating IDA are based on patient weight, as follows: Injectafer contains ferric carboxymaltose, which is a polymer that releases iron into the body. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. This is why family members often have the same issues with drugs as others in theirfamily. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Venofer injection contains iron sucrose, a form of the mineral iron. What to Expect When You Get Your Whole Genome Sequenced, DNA Data Can Help You Understand Ehlers-Danlos Syndrome (EDS). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Call your doctor for medical advice about side effects. Here's some detail on certain side effects this drug may cause. There are currently no generic forms of either drug. Injectafer and Feraheme are both brand-name drugs. He said sometimes the reaction does show up after a few doses and unfortunately it takes longer to get over it. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. If you have iron deficiency anemia (IDA), there are certain foods you can eat that may help increase your iron levels. Usually, when drugs may cause an immune system reaction like this, its a concern with your first dose of the drug. Before you receive Venofer, tell your doctor if you have low blood pressure, hepatitis, or if you have received many blood transfusions in the past. For information on Injectafers effectiveness in treating IDA, see the Injectafer Uses section below. Since someallergic reactionscan belife-threatening, its essential to discuss any adverse events previously experienced with the prescribingphysician. If either is present, do not use the liquid. These lists dont include all possible side effects. Infusion times range from less than 20 minutes to up to 4 hours. For example: Say you weigh 105 pounds (about 48 kilograms). Excessive amounts of Venofer may lead to a condition called iron overload, which may be harmful. If this happens to you, your doctor may recommend that you receive another treatment course of Injectafer. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. Injectafer should be stored between 68F to 77F (20C to 25C). In clinical studies, people who took Injectafer still had iron in their system that was released by the drug 24 days after theyd gotten their injection. In pediatric patients the most common side effects (>2%) are headache, viral respiratory tract infection, peritonitis, upset stomach, throwing up, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension and hypertension (increased blood pressure). So we cant say for sure whether the drug is safe to use while youre pregnant. This way, if you have an allergic reaction to Injectafer, your healthcare professional can treat your reaction. This information should not be used to decide whether or not to take Venofer or any other medicine. Consult your pharmacist or local waste disposal company. They have been a god send. Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in adult and pediatric (2 years of age and older) patients with chronic kidney disease (CKD), and is administered only by or under the supervision of your healthcare provider. <> Hemoglobin is a protein thats found inside your red blood cells. Heres some detail on certain side effects this drug may cause. What to know about iron deficiency anemia, took oral iron treatment and didnt have improvement in their IDA or had side effects that couldnt be managed, or, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, have a medical condition that affects their bodys ability to absorb phosphorus, take medications that affect how well their, ferrous sulfate (Fer-Iron, Slow-FE, Feosol), people who took Injectafer had their hemoglobin level increase by an average of 1.1 grams per deciliter (g/dL), people who took Venofer had their hemoglobin increase by an average of 0.9 g/dL. These nutrients include iron, vitamin B12, and folate. Severeside effectsmay end up causing a lot of disruption in a persons life. With this condition, you also have a low hemoglobin level. Brand-name medications usually cost more than generics. 1xo`[kg'#KS#.#`uv:PM1+Ob`>y/8:6Ghl:y9B+-,9m[ 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. Pain in your limbs. Effectiveness of Injectafer compared with iron thats taken by mouth. Learn how to store and discard medical supplies safely. Potential side effects that are usually mild may include, but are not limited to: Headache Nausea Dry Mouth Stomachache Dizziness Diarrhea Constipation These side effects may not impact life too much and may only be temporary. Although a single administration of FCM frequently causes transient hypophosphatemia, a 2016 study showed that repeated treatment with FCM is associated with a high risk of developing severe and prolonged hypophosphatemia and should therefore be monitored. Injectafer isnt a medication that youll take regularly on a schedule. The drug helps increase your hemoglobin level back to a value thats within the normal range. Erectile dysfunction, anothercommonside effect, can affect life significantly leading to depression and failedrelationships. Side effects are uncomfortable reactions to medications or drugs. I'm contemplating getting infusions again but I've always been a bit worried that they could cause issues in the long run. Other drugs are available that can treat iron deficiency anemia (IDA). But for other people, doing so could lead to having too much iron in their body. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. But its not known whether this poses any risk to a child whos breastfed. Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. After receiving IV iron therapy, you will be monitored for 30 minutes to make sure you do not have an allergic reaction or a drop in blood pressure. Since side effects are similar between 150 mg and 300 mg, a larger dose may increase severity or frequency of side effects. Spacing your Injectafer doses out at least 7 days helps to reduce your risk of side effects. Your doctor will do laboratory tests to monitor your response. Does Venofer Vial interact with other drugs you are taking? The following information is provided for clinicians and other healthcare professionals. In stock alternatives of Venofer (based on Iron Sucrose ) Orofer S 200 Injection 1 Injection in 1 Packet 540 569 5% off. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Click below for effective ways to alleviate the discomfort felt fromside effects and learn how to get a free Medication and Drug Reaction DNAReport. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. And Feraheme is approved for use in adults who have CKD who may or may not need dialysis. For more information and to find out if youre eligible for support, call 877-4-IV-IRON (877-448-4766) or visit the program website. Drug interactions may change how your medications work or increase your risk for serious side effects. The factors influencing how longside effectslast may not provide the answer most are looking for, but it does explain why some people cant take certain medications because theside effectsareunbearable. An LSD comedown is when the mental and hallucinatory effects have worn . Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. For more information on the possible side effects of Injectafer, talk with your doctor or pharmacist. Infusions should be administered over at least 15 minutes. Venofer may reduce the absorption of iron preparations taken by mouth. When the toxins are released into the air, they can be inhaled and cause irritation to the lungs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Your healthcare provider will watch you closely for 30 minutes after each dose. Nausea. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. cough. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Injectafer and Feraheme can cause very similar side effects, but some different ones as well. fever. A lack of iron can lead to iron deficiency anaemia if left untreated. For reasons we dont fully understand, some peoples immune system gets over-activated when the drug enters their body. pain or burning at the injection site. Serious side effects, which are explained in more detail below in Side effect details, include: You may wonder how often certain side effects occur with this drug. No, Injectafer itself wont make you gain weight. Renal elimination is negligible. If you have questions about using Injectafer in a child, talk with your doctor. Hes an expert in genetic testing, genetic analysis, andprecision medicine. Before using, check this product visually for particles or discoloration. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022, Iron is also necessary for your bone marrow to build healthy new red blood cells and provide oxygen to your organs and tissues through hemoglobin, If you or your child has been prescribed Venofer, its based on your blood work, which shows how many red blood cells you have and whether you have enough iron in your blood cells, If you are iron deficient, raising your iron levels can help increase your hemoglobin levels, Treating your anemia may help prevent future health problems, Over time, untreated IDA can cause heart problems; if you already have heart problems, it can make those problems worse, Venofer is given intravenously (through an IV) and
The Injectafer dosage your doctor prescribes will depend on your body weight. This is not a complete list of possible side effects. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. This is a sudden response affecting the entire body, which sometimes happens to people who are allergic to peanuts or beestings. I hope you found answers and are feeling better now. In one study, people were given either Injectafer or an iron replacement drug called Venofer. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: If you have iron deficiency anemia (IDA), consuming moderate amounts of alcohol may be safe, if your doctor tells you its OK. (With IDA, you have a low level of red blood cells thats caused by not having enough iron.). Cancer patients who have anemia and are taking an ESA. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. The signs and symptoms of anaphylaxis include dizziness or fainting, skin flushing and itchiness, difficulty breathing, rapid heart rate, low blood pressure and sudden anxiety. Throw away unused or expired drugs. It is important to get each dose of this medication as scheduled. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Iron sucrose can make it harder for your body to absorb iron medications you take by mouth. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Venofer 100 mg iron/5 mL intravenous solution, Venofer 50 mg iron/2.5 mL intravenous solution, Venofer 200 mg iron/10 mL intravenous solution, Select a condition to view a list of medication options. If you have any of these health problems: Too much iron in your body or anemia from a cause other than low iron. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Knowing how longside effectslast can help with the decision on whether to use a particulardrug. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Allergic reactions typically occur the first time your body is exposed to a drug. Taking a larger dose of LSD can extend the duration of the trip, but generally, the main effects of LSD don't tend to last any longer than 12 hours. Storage Condition Store in a cool and dry place protected from light. Injectafer contains the active drug ferric carboxymaltose. I actually was constipated after my 3rd but didn't think anything of it. With IDA, you have low hemoglobin levels. It belongs to a class of medications known as iron replacement products. Depending on your anemia symptoms, your weight changes may be different than those described here. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. Back pain. Keep in mind that there may be additional costs related to getting your doses of the drug at a medical facility. The infusion will take between 15-30 minutes if it is given in. Call your doctor for medical advice about side effects. Below are examples of these side effects. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). And theyll recommend how soon after starting the drug you need to have this level checked. There are 2 tests that your doctor will likely
It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Its not known how common delayed allergic reaction might be in other people using Injectafer. You may report side effects to Health Canada at 1-866-234-2345. In order for your body to make RBCs, your bone marrow needs a hormone called erythropoietin (EPO). Common side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting; diarrhea; In one study, treatment with Injectafer was compared with that of iron thats taken by mouth. It belongs to a class of medications called iron replacement products. "That's why it's so . You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Low blood pressure. Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. After the infusion, you can drive yourself home and return to your usual activities. This test measures the amount of hemoglobin in your blood. Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Someside effectsare temporary or last as long as the person continues takingprescription medicine. For people with certain medical implants, such as pacemakers, an MRI may pose an . It is very important that your doctor check you closely while you are receiving this medicine. If you have questions about side effects, call your doctor. 2 0 obj But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. However, side effects at the 150 mg dose may indicate that you might not . And this can lead to anemia, including IDA. Injectafer and Venofer are both brand-name drugs. Discuss the risks and benefits with your doctor. All of the people took iron by mouth for 2 weeks. . Injectafer is approved for use in adults who either: Injectafer contains the active drug ingredient ferric carboxymaltose. Patients with celiac disease (gluten intolerance). <> These side effects may include constipation and diarrhea. Which tests can diagnose iron deficiency anemia? (One treatment course includes two doses of the drug.)
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