hydroquinone solubility in glycerin

Thermodyn. Methylaminophenol, used in photography, is produced in this way:[8]. Hydroquinone | C6H4(OH)2 or C6H6O2 | CID 785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Gravimetric method is used to measured hydroquinone solubility in water, ethanol and in water+ethanol binary mixtures at temperatures (293.15, 295.15, 298.15, 300.15, 303.15, 305.15, 308.15, 310.15 and 313.15)K. Mole fractions solubility of hydroquinone are correlated with temperature by using the Apelblat equation. Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. It is moderately soluble in water and highly soluble in alcohol. Have an order or account question, find answers in our Online Support articles. Our team has been notified and we will fix it as soon as possible. 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. Conversion factors (at 25C and normal atmospheric pressure) 1 ppm = 4.5 mg/m 3 1 mg/m 3 = 0.222 ppm Table 1. application/pdf However, the oil-soluble TBHQ is more hydrophobic with a distinctly increased log P value compared to HQ. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. 0000008435 00000 n Crit. Preparation, optimization and in vivo. Dietland Muller-Schwarze, 2003, page 43 (, National Institute for Occupational Safety and Health, Additive manufacturing of ceramics from preceramic polymers, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31976L0768:EN:HTML, "Clear N Smooth Skin Toning Cream recalled", Skin Bleaching Drug Products for Over-the-Counter Product Use; Proposed Rule, "About the Center for Drug Evaluation and Research - Hydroquinone Studies Under The National Toxicology Program (NTP)", Campaign For Safe Cosmetics - Hydroquinone, "Skin lightening preparations and the hydroquinone controversy", https://en.wikipedia.org/w/index.php?title=Hydroquinone&oldid=1136453324, Wikipedia articles needing page number citations from October 2016, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, The most widely used route is similar to the, A potentially significant synthesis of hydroquinone from, Hydroquinone was first obtained in 1820 by the French chemists, Pelletier and Caventou (1820) "Recherches chimiques sur les quinquinas" (Chemical investigations of quinquinas [i.e., the bark of various, This page was last edited on 30 January 2023, at 11:09. Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . 29(3): 283-330, 1999. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25K to 334.45K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. 0000005306 00000 n Consistent with a condensation reaction, water was determined to be the primary byproduct. English, J.C. and Deisinger, P.J. J. Pharm. Gerhard Franz, Roger A. Sheldon "Oxidation" in. Eng. 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. Free format text: Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION Other aspects, advantages, and modifications are evident from a review of the following claims. Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. The natural pH for conventional hydroquinone compositions is acidic, generally less than about 4 even though this is harsh to the skin and to other components of the product. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. 0000008514 00000 n Acta 423, 137144 (2000), S.-T. Lin, S. I. Sandler, Ind. Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150C. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. Phase B: Dissolve the ferulic acid in the glycerin - some "spirited" stirring may be necessary. Hydroquinone, like phenols are very weak acids and can be deprotonated. Data 51, 127129 (2006), J. Lim, S. Jang, H. K. Cho, M. S. Shin, H. Kim, J. Chem. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. ORIGINAL CODE: 0009013, Ref document number: 4. Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. isosorbide, Ascorbic acid, i.e. It is found in wheat, rye, and barley.It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners. Airborne hydroquinone may be oxidized to quinone at ordinary . Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. This website uses cookies. As a polymerisation inhibitor, exploiting its antioxidant properties, hydroquinone prevents polymerization of acrylic acid, methyl methacrylate, cyanoacrylate, and other monomers that are susceptible to radical-initiated polymerization. The combined nearly ideal binary solvent (NIBS)-Redlich-Kister equation is . [33], Hydroquinone has been shown to be one of the chemical constituents of the natural product propolis. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals. Discoloration of hydroquinone compositions may be accelerated by repeated exposure to oxygen or exposing the compositions to high temperatures, which may be found inside a car or delivery vehicle on a hot sunny day. J. Chem. All information collection is solely used to support ChemPoint customers service communications. On this Wikipedia the language links are at the top of the page across from the article title. Read our Privacy Notice. Then take the water and put the measurement into the microwave until boiled. Remove contact lenses, if present and easy to do. Add the hydroquinone to the water. Google Scholar, A.-C. Huang, Y.-K. Chuang, C.-F. Huang, C.-M. Shu, J. Therm. These can be burning, redness, sensitization and irritation in some patients. You can expect to hear from a technical specialist within 1 business hour. The drug is freely soluble in water and in alcohol. Hydroquinone undergoes oxidation under mild conditions to give benzoquinone, process which is reversible. 0000002198 00000 n A preferred embodiment utilizes encapsulation. At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. Some documentation and label information may refer to the legacy brand. 230, 176183 (2005), A. Apelblat, E. Manzurola, N. A. Balal, J. Chem. :hS-g"s2Sj Ij=x'V]gPV8tt~qkAVXi|u}5;#.pl-/4JFQ.EP3&F.qa2hI{N qBmG(z#n [GN.}aazN(~8kux9#tnYwIHFuxW v9UNj&ffNW_\\Tc""8=_"7wC>svwQy\^4gF H][QzmlOI(B@ U4[Xb0,|m0*D"/#$\u(QI)RYg\;8 Yjh Mobility in soil No additional information available 12.5. HlRMo0WB:NnVCnE4(i0 (1* )@NzHR!>i;8XaXnsO0LNT0l$B%"NAb0I9V *6/-\vn0W"fKF:AAgl:psRZ?k`&eB IUQ0ET;W#vL=@XwRG{-LHlTz]^s%OB(GF 11'I The method of item 1 07 wherein the hydroquinone is present in about 4%. Color stability improvement is evident at all levels. The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. [17], An important reaction is the conversion of hydroquinone to the mono- and diamine derivatives. Solute (1 g) Water Boiling Water Alcohol Chloroform Ether Other Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium hydroxide, 15 Acetohexamide 230 210 Acetylcysteine 5 4 Acetyldigitoxin 6100 62.5 12 >10,000 Ammonium Alum 7 0.5 Aluminum Chloride 0.9 4 Aluminum Sulfate 1 Amantadine Hydrochloride 2.5 5.1 18 polyethylene glycol 400, 70 The Density of hydroquinone is . The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and . Phillip M. Hudnall "Hydroquinone" in Ullmann's Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. Classical photo shops . The composition is preferably formulated in separate phases as designated below. HVoLg~Z+ D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. Thermodyn. The solubilities in binary and ternary systems of hydroquinone (1,4-dihydroxybenzene) and p-quinone (1,4-benzoquinone) in supercritical carbon dioxide were measured in the pressure range 10.0 to 35.0 MPa at temperatures of 333, 348 and 363 K.In binary systems, the solubility of hydroquinone was three orders of magnitude lower than that of p-quinone. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. I would like to add retinol and kojic acid to it as well. Continue rinsing.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Avoid release to the environment.WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. Hydroquinone can be made through several routes. volume42, Articlenumber:1 (2021) HYdroquinone can be found in various skin care products. 388, 7381 (2010), H. Li, G. Hu, F. Guo, L. Zhao, J. Zhu, Y. Zhang, Can. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. It is a major component in most black and white photographic developers for film and paper where, with the compound metol, it reduces silver halides to elemental silver. By acting as a free radical scavenger, hydroquinone serves to prolong the shelflife of light-sensitive resins such as preceramic polymers.[18]. While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. https://doi.org/10.1007/s10765-020-02750-4. Hydroquinone is sold by chemical suppliers. Hydroquinone occurs in the environment as a result of anthropogenic processes, as well as in natural products from plants and animals. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. ~lgM~Gc{1S_1Q/_/v">S 9 By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. F. Whler (1844) "Untersuchungen ber das Chinon" (Investigations of quinone). A2, Designated state(s): Int J Thermophys 42, 1 (2021). - 65.21.225.73. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. In the environment, hydroquinone showed increased toxicity for aquatic organisms, being less harmful for bacteria and fungi. Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. PubMedGoogle Scholar. The Campaign for Safe Cosmetics has also highlighted concerns. EP, Kind code of ref document: Hydroquinone is considered to be readily biodegrable and photodegradable. This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 Other properties of hydroquinone are given in Table 1. This compound is gathered from the beaver's castor sacs.[35]. 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. Other adverse effects uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 Antioxidants, preferably sulfites, including but not limited to sulfites, bisulfites, metabisulfites, their salts, and their derivatives, most preferably sodium metabisulfite, have been used to stabilize certain compositions, which have included hydroquinone. Do not put this product in the microwave. 108. 88, 161164 (2010), J. Delgado, Int. Solubility of Hydroquinone. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. Have an order or account question? For more information, please see our It is not to be considered as either a warranty or quality specification. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. The toxicology of hydroquinone - relevance to occupational and environmental exposure. Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. Some hydroquinone compositions include antioxidants, such as ascorbyl palmitate. &"oq YcbX.=a*t R@ As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. Azelaic acid (AzA) is a organic compound with the formula HOOC(CH 2) 7 COOH. Since the neutral pH of the hydroquinone composition with sodium metabisulfite and magnesium ascorbyl phosphate is preferably from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, the pH is acceptable for also including retinoids in the composition. Thank you for your inquiry and interest in ChemPoint. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). 0000003430 00000 n So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. Most preferably, when both a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, are present, the color of the hydroquinone composition is stabilized in the neutral pH range, preferably for greater than about six months, more preferably for greater than about twelve months and most preferably for greater than about eighteen months. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb trailer << /Size 393 /Info 347 0 R /Root 375 0 R /Prev 573815 /ID[<6893db2526a970a0c364cca2e99ca522>] >> startxref 0 %%EOF 375 0 obj << /Type /Catalog /Pages 346 0 R /Metadata 348 0 R >> endobj 391 0 obj << /S 2217 /Filter /FlateDecode /Length 392 0 R >> stream The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. Eng. The obtained results show that the . 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent. Exceptional antioxidant qualities are seen at 0.10% (all percentages in the application are weight percent) and above, preferably from about 0.05% to about 0.5% for sodium metabisulfite. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. [22] The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. Part of Springer Nature. Except where otherwise noted, data are given for materials in their, Hydroquinone oxidation with V2O5/NaClO3/H2SO4, http://www.sciencemadness.org/smwiki/index.php?title=Hydroquinone&oldid=11523, Articles containing unverified chemical infoboxes, GNU Free Documentation License 1.3 or later. ADS C6H4O2) is formed. 0 7 r @ &. LSPS, Laboratoire de Spectrochimie Et Pharmacologie Structurale, University of Tlemcen, BP 119, 13000, Tlemcen, Algeria, Department of Biology, University of Ghardaia, BP 455, 47000, Ghardaia, Algeria, You can also search for this author in However, hydroquinone discolors at the pH range of 7.0 to 8.5. uv curable cellulose estersuv curable cellulose esters . . I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. NR 1L~tyj|ZZ3]jFlszH#bd]="nVj =rBF-=Y?Pe 3(\[3;wR-+7Fn ~pSQ(Rpiw^zYr''t@\vobE]u'C}io0q;^k5C@|zZNNA>,XOrztV;qO*w:MC$OI\_$Io 'v [ I'm using it for spot treatment of some hyper pigmentation (less than 1% of my body). [Na+].OC(=O)CC(O)(CC([O-])=O)C(O)=O.OC(=O)CC(O)(CC([O-])=O)C(O)=O, SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS, Preparations for care of the skin for chemically bleaching or whitening the skin, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Acids; Anhydrides, halides or salts thereof, e.g.

Nicolas Duvalier Net Worth, How To Apply Customer Deposits In Quickbooks, Deerfield Beach Housing Authority, Steven Van Pelt Mt Jefferson, Tiktok Content Moderator Job Uk, Articles H