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Colon cancer (n = 4,326a a Numbers do not add 5,399 due to missing values in dietary variables and cancer site.)



According to the report from WCRF/AICR [In summary, this meta-analysis suggested that dietary nitrates intake was associated with a reduced risk of gastric cancer, and high consumption of nitrites and NDMA could increase the risk. Average waterborne ingested nitrate ranged from 3.4 to 19.7 mg/day, among areas. It also analyzes reviews to verify trustworthiness. … Odd ratios (OR) were calculated using mixed models with area as random effect, adjusted for CRC risk factors and other covariables.



The associations were higher among men, similarly to other exposures such as dietary factors.Confounding by other water contaminants such as THMsAlthough different response rates between study areas and relatively low rates among controls may be a limitation, non‐participation is unlikely related to nitrate exposure. As a result, measurement error in different studies was inevitable, which might contribute to attenuation of the true relationship [As diet is a very complex exposure variable, knowledge of beneficial factors and risk factors provide us an opportunity to improve heath and even prevent cancer. Sold by Amazon.com Services LLC.

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Finally, the main results were robust, as were replicated using different approaches for statistical analysis.Overall, effects of nitrate exposure differed by exposure source (water, vegetables and animal dietary sources). More than 1 million new cases and 694,000 deaths are registered annually in both sexes.We evaluated the association between CRC risk and the exposure to nitrate through drinking water and diet, taking into account endogenous nitrosation factors and other covariates.We pooled data from two case‐control studies conducted in Spain (the Spanish Multi‐case Control study on Cancer, MCC‐Spain)Study subjects were interviewed face‐to‐face by trained study personnel. Interviews were conducted in the hospitals (cases and hospital‐based controls) and in primary health care facilities or nearby research centers (population‐based controls).